Friday, October 22, 2004

Early Clinical Experience for Med Students Could Boost Student Learning,...

"Providing an earlier exposure to clinical experience could strengthen and integrate medical education curriculum, a new study finds, a benefit that would also complement the problem-based learning approach that is becoming more popular in medical education."

Trial Results on Vioxx Do Not Explain Mechanism Behind Adverse Events

"The reason for the increased risk of heart attack and stroke with the withdrawn arthritis drug rofecoxib (Vioxx) is a mystery neither the drug's maker Merck and Co. Inc. nor the U.S. Food and Drug Administration (FDA) has been able to explain."

Inadvertent Fetal Exposure to Antibiotics During Unplanned Pregnancies

Mean gestational duration of the delivered babies was 38.9 ± 2.2 weeks, and mean birth weight was 3405 ± 677 g (range, 1,200 – 5,500 g). Two children were born prematurely at 31 and 35 weeks, with birth weights of 1,200 and 2,300 g, respectively. The baby born at 31 weeks had been exposed to ciprofloxacin, maternal smoking, and multiple x-rays in utero. The other preterm baby had been exposed to gentamicin and nitrofuratoin.



Of the spontaneous abortions, two women had been treated with ciprofloxacin, one woman was treated with ofloxacin, one woman was treated with gentamicin+sulbactam/ampicillin+methenamine, and one woman was treated with ofoxacin+methenamine.



Of the unhealthy babies, a renal anomaly occurred in a baby exposed to ciprofloxacin+gentamicin+methenamine, an atrial septal defect occurred in a baby exposed to methenamine, and congenital hypothyroidism occurred in a baby exposed to ciprofloxacin+nitrofurantoin.

Orlistat and CV Risk in Metabolic Syndrome

"The ORLIstat and CArdiovascular Risk Profile in Patients With Metabolic Syndrome and Type 2 DIAbetes (ORLICARDIA) Study"

Polycystic Ovary Syndrome May Lead to Diabetes, Cardiovascular Disease

"Treating metabolic and cardiovascular risk factors associated with polycystic ovary syndrome (PCOS) could reduce the incidence of serious medical consequences, according to a position statement from the American Association of Clinical Endocrinologists (AACE)."

Hypertension -- Unique Phenotypes and Antihypertensive Treatment

"On the basis of the ALLHAT results, the NHLBI published an update of the national blood pressure guidelines, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7).[4]



These guidelines proposed 2 major new concepts:




* 'Prehypertension'

* Start therapy with a diuretic


Prehypertension. JNC 7 raised the bar for ideal treatment goals by reducing the upper threshold for 'normal' BP to < 120/< 80 mm Hg, compared with < 130/< 85 in JNC 6.[10] This was based on the new realization that cardiovascular (CV) risk begins to rise as soon as BP reaches 115/75 mm Hg and doubles with every increment of 20 mm Hg systolic BP (SBP) and 10 mm diastolic BP (DBP)."

Hypertension -- Unique Phenotypes and Antihypertensive Treatment

"At present approximately 50 million Americans live with blood pressure (BP) levels elevated enough to be considered 'hypertensive.' According to most of the current national guidelines, this means sitting systolic/diastolic blood pressure (SBP/DBP) values > 140/90 mm Hg for nondiabetic individuals and 130/80 mm Hg for those with diabetes.[1-3] Although the proportion of patients who achieve BP control has increased in the past quarter century, control is still low. For example, in the United States it is still only 34%,[4] and control rates are still lower in many other industrialized countries."

Was there a difference in the criteria for diagnosing Hypertension in Diabetics even earlier?

Thursday, October 21, 2004

Nobel Prize for Medicine Awarded to U.S. Scientists for Smell Research

"Two U.S. scientists won the 2004 Nobel prize for medicine on Monday for showing how the sense of smell enables people to recall, for instance, the scent of spring lilac in the winter or the stench of rotten food eaten long ago."

"Humans have just 20,000 to 25,000 genes - well down on previous estimates of 27,000 to 40,000, says the latest analysis of the gene-containing portion of the human genome."