Antimalarial Regimen tolerated well: "Common antimalarial regimens are well tolerated Doxycycline and combined atovaquone and proguanil are the best tolerated of four recommended antimalarial regimens. In a randomised double blind controlled trial Schlagenhauf and colleagues (p 1078) assessed chemoprophylaxis in more than 600 non-immune travellers to sub-Saharan Africa. A high proportion of participants reported adverse events. Skin problems were more common in travellers taking chlorequine and proguanil, and patients taking mefloquine had more neurophysiological adverse events."