Moderate-Intensity Warfarin Appropriate in APA Syndrome

"Moderate-intensity warfarin is appropriate in antiphospholipid antibody (APA) syndrome, according to the results of a trial published in the Sept. 18 issue of the New England Journal of Medicine. Target international normalized ratio (INR) of 2.0 to 3.0 was not associated with higher rates of recurrent thrombosis than was a target of 3.1 to 4.0 in patients with APA syndrome and a previous thrombosis. The editorialists review the knowledge of this syndrome, including issues for which evidence is lacking."