NEJM - Fondaparinux for Symptomatic Pulmonary Embolism: Fondaparinux is a pentasaccharide that selectively inhibits coagulation factor Xa. It is administered by subcutaneous injection and does not require laboratory monitoring. This large study compared fondaparinux and unfractionated heparin in the initial treatment of symptomatic pulmonary embolism. Fondaparinux was as effective and safe as heparin. Fondaparinux may be used as an alternative to intravenous heparin in the initial treatment of hemodynamically stable patients with symptomatic pulmonary embolism"

Selective Factor Xa inhibitor might just get rid of the tedious monitoring associated with heparin therapy - KK